Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: molecular partners that shape immune responses.

Abstract

Schistosome eggs and egg-derived molecules are potent immunomodulatory agents. There is increasing evidence that the interplay between egg glycoproteins and host C-type lectins plays an important role in shaping immune responses during schistosomiasis. As most experiments in this field so far have been performed using complex protein/glycoprotein mixtures or synthetic model glycoconjugates, it is still largely unclear which individual moieties of schistosome eggs are immunologically active. In this review we will discuss molecular aspects of Schistosoma mansoni egg glycoproteins, their interactions with C-type lectins, and the relevance to schistosome egg immunobiology.

• Authors: Moniek H J Meevissen, Maria Yazdanbakhsh, Cornelis H Hokke
• Journal: Experimental parasitology (Exp Parasitol) Vol. 132 Issue 1 Pg. 14-21 (Sep 2012) ISSN: 1090-2449 [Electronic] United States
• PMID: 21616068 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Antigens, Helminth
• Glycoproteins
• Helminth Proteins
• Lectins, C-Type
• Polysaccharides

Topics

• Animals
• Antigens, Helminth (immunology)
• Glycoproteins (immunology)
• Helminth Proteins (immunology)
• Humans
• Lectins, C-Type (immunology)
• Ovum (immunology)
• Polysaccharides (immunology)
• Schistosoma mansoni (immunology)
• Schistosomiasis mansoni (immunology)
• Th2 Cells (immunology)