Abstract | BACKGROUND: METHODS: RESULTS: In the brains of Streptococcus pneumoniae inoculated rats, TrkB mRNA was significantly up-regulated after inoculation for 24 hours, and then down-regulated in a dose-dependent manner after treatment with antibiotics. This up-regulation was seen after treatment with antibiotics plus dexamethasone. TrkB mRNA expression was also observed in some infiltrating inflammatory cells. CONCLUSIONS: The results of the study support the hypothesis that TrkB signal transduction pathways might play an important role in Streptococcus pneumoniae meningitis, probably by protecting the brain from damage. The role of TrkB might be weakened after the treatment with antibiotics. Our findings suggest that targeting TrkB receptors might be a rational strategy for prevention of neurological sequelae caused by Streptococcus pneumoniae meningitis.
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Authors | Ling Li, Quan-Xiang Shui, Zheng-Yan Zhao, Xiao-Dong Zhu, Wei-Qing Bao |
Journal | World journal of pediatrics : WJP
(World J Pediatr)
Vol. 7
Issue 3
Pg. 250-6
(Aug 2011)
ISSN: 1867-0687 [Electronic] Switzerland |
PMID | 21603940
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Dexamethasone
- Receptor, trkB
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Dexamethasone
(pharmacology, therapeutic use)
- Gene Expression
(drug effects)
- Meningitis, Pneumococcal
(drug therapy, genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Receptor, trkB
(biosynthesis, drug effects, genetics)
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