Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men.

Abstract

BACKGROUND:

Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD).

METHODS:

Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were enrolled from inpatients who underwent coronary angiography. Age-matched male subjects (n = 211) having no evidence of CAD served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.

RESULTS:

Plasma A-FABP levels in CAD patients were significantly higher than in control subjects (median [IQR], 20.6 [15.7-27.8] ng/mL vs. 15.1 [11.7-19.9] ng/mL, p < 0.01). Multivariate logistic regression analysis revealed that an increased plasma A-FABP level was independently associated with the presence of CAD in all subjects (adjusted odds ratio: 1.76, 95% confidence interval: 1.14 to 2.70, p = 0.01). Furthermore, sub-analysis based on age showed that this association remained significant in subjects aged < 65 years (adjusted odds ratio: 3.06, 95% confidence interval: 1.34 to 6.98, p < 0.01), but not in subjects aged ≥65 years.

CONCLUSIONS:

Increased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors.

• Authors: Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano, Hiroshi Ito
• Journal: Cardiovascular diabetology (Cardiovasc Diabetol) Vol. 10 Pg. 44 (May 23 2011) ISSN: 1475-2840 [Electronic] England
• PMID: 21600061 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• FABP4 protein, human
• Fatty Acid-Binding Proteins

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Analysis of Variance
• Biomarkers (blood)
• Case-Control Studies
• Chi-Square Distribution
• Coronary Angiography
• Coronary Artery Disease (blood, diagnostic imaging, epidemiology)
• Enzyme-Linked Immunosorbent Assay
• Fatty Acid-Binding Proteins (blood)
• Humans
• Japan (epidemiology)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Risk Assessment
• Risk Factors
• Up-Regulation