Autoimmune progesterone dermatitis: a diagnosis easily missed.

Abstract

Autoimmune progesterone dermatitis (AIPD) is a rare, poorly characterized dermatosis, with about 60 previously reported cases. It typically undergoes cyclical flares relating to the menstrual cycle, especially the luteal phase, when levels of progesterone are at their highest. We report the case of a 34-year-old woman with an 8-year history of a profoundly pruritic eruption, associated with her menstrual cycle, in whom the diagnosis had proved elusive. Buserelin nasal spray resulted in complete clearance. AIPD is a diagnosis to consider in intractable eruptions in women, particularly if there is cyclical variation.

• Authors: L M Toms-Whittle, L H John, D J Griffiths, D A Buckley
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 36 Issue 4 Pg. 378-80 (Jun 2011) ISSN: 1365-2230 [Electronic] England
• PMID: 21564176 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author(s). CED © 2010 British Association of Dermatologists.

Chemical References

• Gonadotropin-Releasing Hormone
• Progesterone
• Buserelin

Topics

• Adult
• Autoimmune Diseases (drug therapy, immunology, pathology)
• Buserelin (therapeutic use)
• Dermatitis
• Female
• Gonadotropin-Releasing Hormone (therapeutic use)
• Humans
• Menstrual Cycle (immunology)
• Progesterone (adverse effects, immunology)
• Time Factors
• Treatment Outcome