Long-term mortality in adult orthotopic heart transplant recipients.

Abstract

Heart transplantation is now regarded as the treatment of choice for end-stage heart failure. To improve long-term results of the heart transplantation, we analyzed causes of death relative to time after transplantation. A total of 201 consecutive patients, 154 (76.6%) males, aged ≥ 17 yr underwent heart transplantation between November 1992 and December 2008. Mean ages of recipients and donors were 42.8 ± 12.4 and 29.8 ± 9.6 yr, respectively. The bicaval anastomosis technique was used since 1999. Mean follow up duration was 6.5 ± 4.4 yr. Two patients (1%) died in-hospital due to sepsis caused by infection. Late death occurred in 39 patients (19.4%) with the most common cause being sepsis due to infection. The 1-, 5-, and 10-yr survival rates in these patients were 95.5% ± 1.5%, 86.9% ± 2.6%, and 73.5% ± 4.1%, respectively. The surgical results of heart transplantation in adults were excellent, with late mortality due primarily to infection, malignancy, and rejection. Cardiac deaths related to cardiac allograft vasculopathy were very rare.

• Authors: Sung-Ho Jung, Jae Joong Kim, Suk Jung Choo, Tae-Jin Yun, Cheol Hyun Chung, Jae Won Lee
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 26 Issue 5 Pg. 599-603 (May 2011) ISSN: 1598-6357 [Electronic] Korea (South)
• PMID: 21532848 (Publication Type: Journal Article)

Topics

• Adult
• Anastomosis, Surgical (methods)
• Female
• Follow-Up Studies
• Graft Rejection (mortality)
• Heart Transplantation (mortality)
• Humans
• Immunosuppression Therapy (methods)
• Infections (mortality)
• Male
• Middle Aged
• Neoplasms (mortality)
• Postoperative Complications (mortality, surgery)
• Survival Rate
• Transplantation (mortality)
• Treatment Outcome