Abstract | INTRODUCTION: CASE REPORT: A 38-year-old patient with MELAS and SLEs was treated with oral L-arginine and idebenone for 27months. She remained free of attacks throughout the treatment period except when she stopped her treatment on two occasions during which she had recurrent cerebral metabolic attacks. The patient experienced no side effect of treatment with L-arginine and idebenone. CONCLUSION: Our observation suggests long-term safety and potential benefit of oral L-arginine and idebenone in the prevention of recurrence of SLEs in adult MELAS patients.
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Authors | A Lekoubou, A-E Kouamé-Assouan, T-H Cho, J Luauté, N Nighoghossian, L Derex |
Journal | Revue neurologique
(Rev Neurol (Paris))
Vol. 167
Issue 11
Pg. 852-5
(Nov 2011)
ISSN: 0035-3787 [Print] France |
PMID | 21514942
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antioxidants
- Drug Combinations
- Ubiquinone
- Arginine
- idebenone
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Topics |
- Administration, Oral
- Adult
- Antioxidants
(administration & dosage, pharmacology)
- Arginine
(administration & dosage, pharmacology)
- Drug Combinations
- Female
- Humans
- MELAS Syndrome
(complications, drug therapy)
- Stroke
(etiology, prevention & control)
- Time Factors
- Treatment Outcome
- Ubiquinone
(administration & dosage, analogs & derivatives, pharmacology)
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