Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis.

Abstract

PURPOSE:

To evaluate what is useful among various parameters including CT findings, laboratory parameters (%VC, %DLco, KL-6), patients related data (age, sex, duration of disease) to discriminate between responder and non-responder in patients who received autologous peripheral blood stem cell transplantation (auto-PBSCT) for interstitial pneumonia (IP) with systemic sclerosis (SSc).

METHOD:

Auto-PBSCT and follow-up of at least one year by chest CT, serum KL-6, %VC, and %DLco were performed in 15 patients for IP with SSc. Analyzed CT findings included extent of ground-glass opacity (GGO), intralobular reticular opacity, number of segments that showed traction bronchiectasis, and presence of honeycombing. We regarded the therapeutic response of patients as responders when TLC or VC increase over 10% or DLco increase more than 15%, otherwise we have classified as non-responder. We applied univariate and multivariate analyses to find the significant indicators to discriminate responders from non-responders. P<0.05 was considered statistically significant.

RESULTS:

Univariate and multivariate analyses showed that the significant parameter to discriminate responders from non-responders were pretreatment KL-6, presence of honeycombing, extent of GGO, and early change in extent of GGO. Among them, extent of GGO and early change in extent of GGO were the strongest discriminators between responders and non-responders (P=0.001, 0.001, respectively).

CONCLUSION:

Several CT findings and pretreatment KL-6 may be useful to discriminate between responder and non-responder in patients who received auto-PBSCT for IP with SSc.

• Authors: Hidetake Yabuuchi, Yoshio Matsuo, Hiroshi Tsukamoto, Shunya Sunami, Takeshi Kamitani, Shuji Sakai, Masamitsu Hatakenaka, Koji Nagafuji, Takahiko Horiuchi, Mine Harada, Koichi Akashi, Hiroshi Honda
• Journal: European journal of radiology (Eur J Radiol) Vol. 79 Issue 2 Pg. e74-9 (Aug 2011) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 21514756 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Topics

• Adult
• Female
• Humans
• Logistic Models
• Lung Diseases, Interstitial (diagnostic imaging, etiology, therapy)
• Male
• Middle Aged
• Peripheral Blood Stem Cell Transplantation
• Retrospective Studies
• Scleroderma, Systemic (complications, diagnostic imaging, therapy)
• Tomography, X-Ray Computed (methods)
• Transplantation, Autologous
• Treatment Outcome