[A case of recurrent gastric cancer with lymph node metastasis successfully treated by CPT-11/CDDP therapy].

Abstract

We report a case ofa 76-year-old man suffering from advanced gastric cancer with lymph node recurrence. Distal gastrectomy was performed for gastric cancer with pylorus stenosis in April 2001. Pathological staging was III A(T3, N1, M0, Cur B). He underwent outpatient treatment with oral administration of UFT 400mg/day as postoperative adjuvant chemotherapy, but stopped after two months because of loss of appetite and general fatigue. Partial liver resection(S4/5)was performed for liver metastasis(S4)in June 2002, and S-1 was administered 80mg/day as adjuvant chemotherapy. However, obstructive jaundice was detected for lymph node recurrence in March 2003, and conducted bile duct stent after PTCD. He started to undergo a biweekly combination chemotherapy of irinotecan (CPT-11)60mg/m / 2 and cisplatin(CDDP)30mg/m2. Three months later, the lymph node had decreased in size. We reduced this therapy, extended the interval, and discontinued it after 24 courses due to adverse reactions, such as leucopenia(grade 3)and general fatigue(grade 2). Afterward, he had no recurrence for over 5 years.

• Authors: Ho Min Kim, Yutaka Kimura, Toshiyuki Kanoh, Tadashi Ohnishi, Takeshi Tono, Yoshiaki Nakano, Hiroshi Yano, Takushi Monden, Shingi Imaoka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 4 Pg. 651-4 (Apr 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21498998 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Irinotecan
• Cisplatin
• Camptothecin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives, therapeutic use)
• Cisplatin (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Humans
• Irinotecan
• Lymphatic Metastasis
• Male
• Recurrence
• Remission Induction
• Salvage Therapy
• Stomach Neoplasms (drug therapy, pathology, surgery)