Abstract | OBJECTIVE: DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): INTERVENTION(S): Samples of endometrial and endometriotic tissue from women with endometrioma (n=48), and endometrial samples from women without endometriosis (controls) (n=48). MAIN OUTCOME MEASURE(S): RESULT(S): The eutopic endometrium of patients with endometriosis showed [1] higher activin A mRNA expression in the proliferative phase and a lack of late secretory phase peak, [2] a lack of endometrial cycle-related variations of cripto and inhibin α mRNA expression, and [3] an inverse expression pattern of follistatin mRNA. Endometriomas showed similar variations in the expression of activin-related protein mRNA during the menstrual cycle as eutopic endometrium. CONCLUSION(S):
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Authors | Ana Luiza L Rocha, Patrizia Carrarelli, Romina Novembri, Lorenzo Sabbioni, Stefano Luisi, Fernando M Reis, Felice Petraglia |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 95
Issue 7
Pg. 2241-6
(Jun 2011)
ISSN: 1556-5653 [Electronic] United States |
PMID | 21496809
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- FST protein, human
- Follistatin
- GPI-Linked Proteins
- Intercellular Signaling Peptides and Proteins
- Neoplasm Proteins
- RNA, Messenger
- TDGF1 protein, human
- activin A
- activin B
- inhibin-alpha subunit
- Activins
- Inhibins
- Activin Receptors, Type II
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Topics |
- Activin Receptors, Type II
(genetics)
- Activins
(genetics)
- Adult
- Analysis of Variance
- Brazil
- Case-Control Studies
- Endometriosis
(genetics, pathology, physiopathology)
- Female
- Follistatin
(genetics)
- GPI-Linked Proteins
(genetics)
- Gene Expression Regulation, Neoplastic
- Hospitals, University
- Humans
- Inhibins
(genetics)
- Intercellular Signaling Peptides and Proteins
(genetics)
- Menstrual Cycle
- Neoplasm Proteins
(genetics)
- Prospective Studies
- RNA, Messenger
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
- Uterine Diseases
(genetics, pathology, physiopathology)
- Young Adult
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