Abstract | BACKGROUND AND OBJECTIVE: MATERIAL AND METHODS: Forty white rabbits were alloted into groups: (i) seven-day (cIVA injection of fasudil hydrochloride for seven days after injection of blood) group, (ii) five-day (cIVA injection of fasudil hydrochloride for five days from the third day after injection of blood) group, (iii) intravenous treatment ( intravenous infusion of fasudil hydrochloride after the first blood injection twice a day) group, and (iv) control group. All the rabbits in all the four groups underwent selective vertebrobasilar angiography. The pathological changes in the basal artery were observed by light and electron microscopy. Fasudil hydrochloride injection (2ml:30mg) was provided by Tianjin Chase Sun Pharmaceutical Company Limited. RESULTS: CONCLUSIONS:
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Authors | Peng Liu, Xuxing Liao, Jianwei Xiang, Li Pan, Lianting Ma |
Journal | Neurology India
(Neurol India)
2011 Mar-Apr
Vol. 59
Issue 2
Pg. 161-7
ISSN: 0028-3886 [Print] India |
PMID | 21483110
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- fasudil
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Topics |
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
(administration & dosage, analogs & derivatives, therapeutic use)
- Animals
- Cerebral Angiography
- Cerebrovascular Circulation
- Disease Models, Animal
- Injections, Intra-Arterial
- Rabbits
- Treatment Outcome
- Vasodilator Agents
(administration & dosage, therapeutic use)
- Vasospasm, Intracranial
(diagnostic imaging, drug therapy)
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