Molecular and clinical characteristics of hemoglobin Ottawa detected in a Chinese population.

Abstract

Hemoglobin (Hb) Ottawa [α15 (A13) Gly→Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, there have been no reports of Hb Ottawa in mainland China in the English literature. Hb Ottawa results from a GGT→CGT mutation in codon 15 of the α1 or α2-globin gene. Hb Ottawa carriers do not present any clinical symptoms or hematological changes, and are often diagnosed during a health examination and thalassemia screening. In a hemoglobin survey of 9745 students in Chaozhou, Guangdong, China, we identified four cases of Hb Ottawa in a thalassemia screening by Hb electrophoresis, and confirmed it to be the result of a GGT→CGT mutation in codon 15 of the α2-globin gene by DNA sequence analysis.

• Authors: Yue Huang, Min Lin, Chun-Ping Lin, Jiao-Ren Wu, Luo-Han Zheng, Li-Ye Yang
• Journal: Molecular medicine reports (Mol Med Rep) 2011 May-Jun Vol. 4 Issue 3 Pg. 581-3 ISSN: 1791-3004 [Electronic] Greece
• PMID: 21468611 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hemoglobins, Abnormal
• hemoglobin Siam

Topics

• Adolescent
• Asian People (genetics)
• Base Sequence
• Child
• China
• Female
• Hemoglobins, Abnormal (genetics)
• Humans
• Male
• Molecular Sequence Data
• Sequence Analysis, DNA
• Young Adult