HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

DNMT3A mutations in acute myeloid leukemia.

Abstract
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
AuthorsMrinal Y Shah, Jonathan D Licht
JournalNature genetics (Nat Genet) Vol. 43 Issue 4 Pg. 289-90 (Mar 29 2011) ISSN: 1546-1718 [Electronic] United States
PMID21445072 (Publication Type: News, Comment)
Chemical References
  • DNMT3A protein, human
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
Topics
  • DNA (Cytosine-5-)-Methyltransferases (genetics)
  • DNA Methylation
  • DNA Methyltransferase 3A
  • Epigenesis, Genetic
  • Hematopoiesis (genetics)
  • Humans
  • Leukemia, Myeloid, Acute (enzymology, genetics)
  • Models, Genetic
  • Mutation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: