Abstract |
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
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Authors | Mrinal Y Shah, Jonathan D Licht |
Journal | Nature genetics
(Nat Genet)
Vol. 43
Issue 4
Pg. 289-90
(Mar 29 2011)
ISSN: 1546-1718 [Electronic] United States |
PMID | 21445072
(Publication Type: News, Comment)
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Chemical References |
- DNMT3A protein, human
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methyltransferase 3A
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Topics |
- DNA (Cytosine-5-)-Methyltransferases
(genetics)
- DNA Methylation
- DNA Methyltransferase 3A
- Epigenesis, Genetic
- Hematopoiesis
(genetics)
- Humans
- Leukemia, Myeloid, Acute
(enzymology, genetics)
- Models, Genetic
- Mutation
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