Abstract | BACKGROUND/AIMS: Sulfation is considered to be a detoxifying mechanism for bile acids, which allows the sulfated bile acids to be eliminated in the urine (urinary sulfated bile acids: USBA) by enhancing renal clearance when serum bile acids increase due to hepatobiliary disease. We measured urinary sulfated bile acids in patients positive for hepatitis C virus and studied the relation between USBA and standard liver function tests. METHODOLOGY: Seventy-eight outpatients could be followed for at least one year were enrolled in this study. Blood and urine samples were simultaneously obtained from the patients. The measured urinary sulfated bile acids levels were adjusted for the urinary creatinine concentration and the normal value was defined <8 micromol/g creatinine. RESULTS: CONCLUSIONS: Urinary sulfated bile acids are considered to be a useful diagnostic indicator of impaired liver function, and can also be used to assess the severity of hepatic disease.
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Authors | Tamiko Tetsutani, Kenichi Adachi, Takeshi Suzuki, Sachie Kiyohara |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2010 Nov-Dec
Vol. 57
Issue 104
Pg. 1483-8
ISSN: 0172-6390 [Print] Greece |
PMID | 21443107
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bile Acids and Salts
(urine)
- Circadian Rhythm
- Female
- Hepatitis C
(urine)
- Humans
- Liver Function Tests
- Male
- Middle Aged
- Statistics, Nonparametric
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