Omega-3 fatty acids supplementation does not affect serum lipids in chronic hemodialysis patients.

Abstract

OBJECTIVE:

The aim of this study was to test the hypothesis that omega-3 fatty acids have an effect on serum lipids and inflammation markers in chronic hemodialysis (HD) patients.

DESIGN:

The study followed a single-blind, randomized, crossover design.

SETTING:

The study was conducted at the Hemodialysis Unit of the Laikon General Hospital in Athens, Greece.

PATIENTS:

A total of 25 chronic HD patients were included in the study (16 men, 9 women, age: 51 ± 15 years).

INTERVENTION:

Patients were randomly assigned to one of the following 2 intervention groups: omega-3 fatty acids plus α-tocopherol (920 mg eicosapentaenoic Acid (EPA), 760 mg docosahexaenoic acid (DHA), 8 mg α-tocopherol in total per day) or α-tocopherol supplement (100 mg/week resulting in 14.2 mg/day) alone for 4 weeks. After a washout period of 4 weeks, the 2 groups were crossed.

MAIN OUTCOME MEASURES:

Medical history data were collected and anthropometric and nutritional intake evaluation was performed at the beginning and at the end of both interventions. Hematological and biochemical parameters as well as C-reactive protein levels were measured.

RESULTS:

No statistically significant results were recorded in the lipidemic profiles of the participants between baseline and the 2 interventions. C-reactive protein levels also did not change significantly between the 2 interventions (5.54 ± 3.33 to 6.70 ± 5.01 mg/L [P = .19] with vitamin E vs. 7.13 ± 5.04 to 6.87 ± 5.24 [P = .78] with omega-3, P overall = .53).

CONCLUSION:

The results of this study do not provide support for the positive effects of omega-3 fatty acid supplementation in HD patients.

• Authors: Kalliopi-Anna Poulia, Demosthenes B Panagiotakos, Eleftheria Tourlede, Athanasia Rezou, Dimitrios Stamatiadis, John Boletis, Antonis Zampelas
• Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (J Ren Nutr) Vol. 21 Issue 6 Pg. 479-84 (Nov 2011) ISSN: 1532-8503 [Electronic] United States
• PMID: 21439849 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Vitamin E
• Docosahexaenoic Acids
• C-Reactive Protein
• Eicosapentaenoic Acid
• alpha-Tocopherol

Topics

• Adult
• Aged
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Cross-Over Studies
• Dietary Supplements
• Docosahexaenoic Acids (administration & dosage, blood)
• Eicosapentaenoic Acid (administration & dosage, blood)
• Female
• Greece
• Humans
• Inflammation (physiopathology)
• Kidney Failure, Chronic (drug therapy)
• Male
• Middle Aged
• Renal Dialysis
• Single-Blind Method
• Vitamin E (administration & dosage)
• alpha-Tocopherol (administration & dosage)