Influence of age and short-term starvation on the ATPase activity in the developing rat brain.

Abstract

Na+-K+-stimulated and Mg++-dependent ATPase activities were investigated in the developing cerebral cortex, subcortical structures, and medulla oblongata of rats as was the effect of 24-hr lasting starvation and thirst on those enzyme activities. We found (a) a developmental increase of these ATPase activities in the developing rat brain with the maximum in the cerebral cortex and with the minimum in the medulla oblongata; (b) a decrease of the ratio of these enzyme activities, which was near unity in adult animals; (c) an increase of ATPase activities in the cerebral cortex and subcortical formations of young rats under starvation conditions followed by a decrease of the Mg++/Na+-K+-ATPase activity ratios in these structures; and (d) a decrease of these activities, especially in the cerebral cortex, and an increase of the activity ratios in adult animals under starvation conditions.

• Authors: J Mourek, F Stastný
• Journal: Developmental psychobiology (Dev Psychobiol) Vol. 11 Issue 6 Pg. 587-93 (Nov 1978) ISSN: 0012-1630 [Print] United States
• PMID: 214366 (Publication Type: Journal Article)

Chemical References

• Sodium-Potassium-Exchanging ATPase
• Magnesium

Topics

• Age Factors
• Animals
• Brain (enzymology, growth & development)
• Cerebral Cortex (enzymology)
• Magnesium (pharmacology)
• Medulla Oblongata (enzymology)
• Rats
• Sodium-Potassium-Exchanging ATPase (metabolism)
• Starvation (enzymology)