Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects.

Abstract

OBJECTIVES:

Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension.

METHODS:

The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2278 Japanese normotensive male subjects with a follow-up of 3 years.

RESULTS:

Of the 2278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17-1.79, P < 0.01). In addition, baPWV values >1380 cm/s indicated a high risk for incident hypertension.

CONCLUSIONS:

Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.

• Authors: Hiroki Satoh, Yasuaki Saijo, Reiko Kishi, Hiroyuki Tsutsui
• Journal: Environmental health and preventive medicine (Environ Health Prev Med) Vol. 16 Issue 4 Pg. 217-23 (Jul 2011) ISSN: 1347-4715 [Electronic] Japan
• PMID: 21431793 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adult
• Ankle Brachial Index (methods, standards)
• Blood Pressure
• Brachial Artery (physiopathology)
• Follow-Up Studies
• Humans
• Hypertension (diagnosis, physiopathology)
• Japan
• Male
• Middle Aged
• Odds Ratio
• Predictive Value of Tests
• Reference Values
• Surveys and Questionnaires
• Tibial Arteries (physiopathology)