Abstract |
Renal strong ion compensation to chronic respiratory acidosis has been established, but the nature of the response to acute respiratory acidosis is not well defined. We hypothesized that the response to acute respiratory acidosis in sheep is a rapid increase in the difference in renal fractional excretions of chloride and sodium (Fe(Cl) - Fe(Na)). Inspired CO(2) concentrations were increased for 1 h to significantly alter P(a)CO(2) and pH(a) from 32 ± 1 mm Hg and 7.52 ± 0.02 to 74 ± 2 mm Hg and 7.22 ± 0.02, respectively. Fe(Cl) - Fe(Na) increased significantly from 0.372 ± 0.206 to 1.240 ± 0.217% and returned to baseline at 2 h when P(a)CO(2) and pH(a) were 37 ± 0.6 mm Hg and 7.49 ± 0.01, respectively. Arterial pH and Fe(Cl) - Fe(Na) were significantly correlated. We conclude that the kidney responds rapidly to acute respiratory acidosis, within 30 min of onset, by differential reabsorption of sodium and chloride.
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Authors | Jayanth Ramadoss, Randolph H Stewart, Timothy A Cudd |
Journal | Canadian journal of physiology and pharmacology
(Can J Physiol Pharmacol)
Vol. 89
Issue 3
Pg. 227-31
(Mar 2011)
ISSN: 1205-7541 [Electronic] Canada |
PMID | 21423296
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acidosis, Respiratory
(metabolism, physiopathology)
- Acute Disease
- Animals
- Chlorides
(metabolism)
- Kidney
(metabolism, physiopathology)
- Sheep
- Sodium
(metabolism)
- Time Factors
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