Abstract | BACKGROUND: METHODS: Human plasma gelsolin (pGSN, 10mg in 1ml saline) was administered once immediately following surgery, and control 2CLP (2CLP Alb) and sham animals were injected with 1ml saline containing equimolar albumin. Treatments were administered intraperitoneally (IP), intravenously (IV), or subcutaneously (SC). RESULTS:
Gelsolin levels in the 2CLP Alb group were lower than in sham animals. Administration of pGSN increased levels when administered IV and SC, but not IP. Morbidity scores were significantly less severe in the 2CLP pGSN group than in the 2CLP Alb group when pGSN was administered IV and SC, but not IP. Furthermore, enzymatic activity indicative of tissue damage ( lactate dehydrogenase and alanine transaminase) was significantly lower in 2CLP pGSN group when treated SC compared to 2CLP Alb group. CONCLUSION: These data provide further evidence that exogenous gelsolin can reduce morbidity from sepsis.
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Authors | Taylor S Cohen, Robert Bucki, Fitzroy J Byfield, Nicholas J Ciccarelli, Brenna Rosenberg, Mark J DiNubile, Paul A Janmey, Susan S Margulies |
Journal | Cytokine
(Cytokine)
Vol. 54
Issue 3
Pg. 235-8
(Jun 2011)
ISSN: 1096-0023 [Electronic] England |
PMID | 21420877
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Gelsolin
- L-Lactate Dehydrogenase
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(metabolism)
- Animals
- Cytokines
(biosynthesis, metabolism)
- Disease Models, Animal
- Gelsolin
(administration & dosage, blood)
- Humans
- Inflammation
- Infusions, Intravenous
- Infusions, Parenteral
- L-Lactate Dehydrogenase
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Sepsis
(drug therapy)
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