Vascular endothelial growth factors and angiopoietins in presentations and prognosis of papillary thyroid carcinoma.

Abstract

AIMS:

Angiogenesis from thyroid cancer cell plays the important roles in post-surgical persistent, recurrent, and metastatic papillary thyroid cancer (PTC). This study is to investigate the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tek/Tie-2 receptor, and vascular endothelial growth factors (VEGF) in normal, benign thyroid tissues and different stage of PTC. We expect angiogenetic factors are important in the presentation of local-regional neck or distant metastases in PTC.

MATERIALS AND RESULTS:

A total of 101 tissues from the subjects underwent thyroidectomy were enrolled in the study. There were 22 control and 79 thyroid cancer patients in different TNM stagings were collected. Ang-1 illustrated highest mean immunostaining score in metastatic group. Comparing with normal and benign thyroid tissues, thyroid cancer tissues illustrated significantly high expression of three angiogenetic factors and Tie-2 receptor. Of the PTC, significantly high expression of three angiogenetic factors and Tie-2 receptor were illustrated in recurrent cases. VEGF showed statistical difference in disease-free cancer mortality, and recurrent groups.

CONCLUSIONS:

Immunochemical staining illustrated VEGF, Ang-1, Ang-2 expression in PTC tissues related to clinical staging; however, we need more information concerning these factors with long-term follow-up results.

• Authors: Chuen Hsueh, Jen-Der Lin, I-Chin Wu, Tzu-Chieh Chao, Jau-Song Yu, Miaw-Jene Liou, Chi-Ju Yeh
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 103 Issue 5 Pg. 395-9 (Apr 2011) ISSN: 1096-9098 [Electronic] United States
• PMID: 21400522 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 Wiley-Liss, Inc.

Chemical References

• Angiopoietin-1
• Angiopoietin-2
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Receptor, TIE-2

Topics

• Adult
• Angiopoietin-1 (metabolism)
• Angiopoietin-2 (metabolism)
• Carcinoma
• Carcinoma, Papillary
• Case-Control Studies
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (metabolism, pathology, surgery)
• Neoplasm Staging
• Prognosis
• Receptor, TIE-2 (metabolism)
• Survival Rate
• Thyroid Cancer, Papillary
• Thyroid Gland (metabolism, pathology, surgery)
• Thyroid Neoplasms (metabolism, pathology, secondary, surgery)
• Thyroidectomy
• Vascular Endothelial Growth Factor A (metabolism)