Impact of IL-18 on inflammation.

Abstract

IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.

• Authors: D Tripodi, G Maccauro, A Anogeianaki, M L Castellani, F Pandolfi, P Felaco, E Toniato, M A De Lutiis, M Fulcheri, S Tetè, R Galzio, V Salini, A Caraffa, P Antinolfi, I Frydas, G Sabatino, Y B Shaik-Dasthagirisaheb
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2011 Jan-Mar Vol. 25 Issue 1 Pg. 7-11 ISSN: 0393-974X [Print] Italy
• PMID: 21382268 (Publication Type: Editorial)

Chemical References

• Interleukin-18
• Lipopolysaccharides

Topics

• Animals
• Arthritis, Rheumatoid (immunology)
• Dendritic Cells (immunology)
• Humans
• Hypersensitivity (immunology)
• Inflammation (immunology)
• Interleukin-18 (immunology)
• Keratinocytes (immunology)
• Kupffer Cells (immunology)
• Lipopolysaccharides (pharmacology)
• Lymphocyte Activation (drug effects, immunology)