Pan-resistant Acinetobacter baumannii mediastinitis treated successfully with tigecycline: a case report.

Abstract

BACKGROUND:

Mediastinitis due to Acinetobacter baumannii is rare.

METHODS:

We report a case of mediastinitis caused by pan-resistant A. baumannii in a patient with multiple comorbidities who underwent cardiopulmonary bypass and we also present a literature review.

RESULTS:

Successful treatment consisted of surgical debridement plus drainage, and tigecycline administration for three weeks.

CONCLUSION:

Surgical source control along with effective antibiotics is essential in the treatment of mediastinitis. Tigecycline has the potential to be an option for pan-resistant A. baumannii mediastinitis.

• Authors: Ayşe Yasemin Tezer Tekçe, Ayşe Erbay, Hatice Çabadak, Serap Yağcı, Nihal Karabiber, Süha Şen
• Journal: Surgical infections (Surg Infect (Larchmt)) Vol. 12 Issue 2 Pg. 141-3 (Apr 2011) ISSN: 1557-8674 [Electronic] United States
• PMID: 21348768 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Tigecycline
• Minocycline

Topics

• Acinetobacter Infections (diagnosis, drug therapy, microbiology, surgery)
• Acinetobacter baumannii (drug effects, isolation & purification)
• Anti-Bacterial Agents (administration & dosage)
• Cardiopulmonary Bypass (adverse effects)
• Debridement
• Drainage
• Drug Resistance, Multiple, Bacterial
• Female
• Humans
• Mediastinitis (diagnosis, drug therapy, microbiology, surgery)
• Middle Aged
• Minocycline (administration & dosage, analogs & derivatives)
• Surgical Wound Infection (diagnosis, drug therapy, microbiology, surgery)
• Tigecycline
• Treatment Outcome