Poly(diol-co-citrate)s as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia.

Abstract	The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.
Authors	M Concepcion Serrano, Ashley K Vavra, Michele Jen, Melissa E Hogg, Jozef Murar, Janet Martinez, Larry K Keefer, Guillermo A Ameer, Melina R Kibbe
Journal	Macromolecular bioscience (Macromol Biosci) Vol. 11 Issue 5 Pg. 700-9 (May 12 2011) ISSN: 1616-5195 [Electronic] Germany
PMID	21341372 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Copyright	Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References	Azo Compounds Delayed-Action Preparations Drug Carriers Elastomers Nitric Oxide Donors Polyesters Triazenes Nitric Oxide
Topics	Animals Azo Compounds (administration & dosage, pharmacology) Carotid Artery Injuries (drug therapy, pathology) Carotid Artery, Common (drug effects, pathology) Cell Survival (drug effects) Cells, Cultured Delayed-Action Preparations Drug Carriers Elastomers (chemistry) Humans Hyperplasia (prevention & control) Implants, Experimental Male Materials Testing Neointima (pathology) Nitric Oxide (metabolism) Nitric Oxide Donors (administration & dosage, pharmacology) Polyesters (chemistry) Rats Rats, Sprague-Dawley Tensile Strength Triazenes (chemistry)

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