Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp.

Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

• Authors: Yung-Husan Chen, Chia-Ying Tai, Tsong-Long Hwang, Ching-Feng Weng, Jan-Jung Li, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu, Ping-Jyun Sung
• Journal: Marine drugs (Mar Drugs) Vol. 8 Issue 12 Pg. 2936-45 (Dec 06 2010) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 21339957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Diterpenes
• cladielloide A
• cladielloide B
• eunicellin
• Superoxides
• Leukocyte Elastase

Topics

• Animals
• Anthozoa (chemistry)
• Anti-Inflammatory Agents, Non-Steroidal (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Diterpenes (chemistry, isolation & purification, pharmacology)
• HL-60 Cells
• Humans
• Indonesia
• Leukemia P388
• Leukocyte Elastase (metabolism)
• Molecular Structure
• Neutrophils (drug effects, metabolism)
• Superoxides (metabolism)