To report the changes seen in the photoreceptor layer during the acute phase of
sympathetic ophthalmia. Six consecutive patients diagnosed with
sympathetic ophthalmia were enrolled in the study. All 6 patients had a fundus
fluorescein angiogram and spectral domain optical coherence tomography (OCT) scan carried out at presentation. The outer
retinal segment was demarcated on the raster line scan between the external limiting membrane (ELM) and the retinal pigment epithelium (RPE)-choriocapillaris complex. All patients received intravenous
methylprednisolone followed by oral
corticosteroids 1-1.5 mg/kg/day. The serial follow-up OCT scans taken 48 h after the initiation of treatment, and 1, 2 and 12 weeks later, were studied and compared. The retina inner to the ELM did not show any remarkable structural alteration in any of the eyes. The outer
retinal segment demarcated by the ELM and the RPE-choriocapillaris complex showed serous
retinal detachment in all the eyes and elongation of photoreceptors could be seen in four eyes. There was a disruption to the continuity of the two inner hyper-reflective bands in all the eyes. A repeat raster line scan performed 48 h after systemic
corticosteroid therapy showed a reduction in the height of the serous
retinal detachment with elongation of photoreceptors and the protrusion of their apical segments into the serous detachment in 4 eyes. The serous detachment showed a progressive reduction in height following intravenous methyprednisolone
therapy in all the eyes over the following week with elongated photoreceptors in all six eyes. After two weeks, none of the eyes showed any residual detachment and this corresponded with the improvement in visual acuity in all the eyes. OCT raster line scans repeated at 4 weeks showed resolution of serous detachment with normal photoreceptor layer and restoration of a third hyper-reflective band (IS/OS junction) in all the eyes. The photoreceptor layer is involved during the acute phase of
sympathetic ophthalmia as indicated by the in vivo morphological changes seen on spectral domain OCT. These changes are reversible following systemic
corticosteroid therapy thus supporting the hypothesis that prompt and aggressive anti-inflammatory
therapy is capable of reversing the photoreceptor changes.