Abstract | BACKGROUND AND PURPOSE: METHODS: Serum homoarginine was measured in 3305 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study who were referred to coronary angiography at baseline (1997 to 2000) and were followed up with respect to mortality. RESULTS: During a median follow-up time of 9.9 years, 991 patients died including 61 fatal (ischemic and hemorrhagic) strokes. In a binary logistic regression analysis, the odds ratio (with 95% CI) for fatal stroke per SD of homoarginine was 0.52 (0.37 to 0.73; P<0.001) and remained significant after multivariable adjustments (0.62 [0.42 to 0.91]; P=0.014). For previous cerebrovascular disease events, the multivariable adjusted OR per SD of homoarginine was 0.82 (0.70 to 0.96; P=0.014). CONCLUSIONS:
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Authors | Stefan Pilz, Andreas Tomaschitz, Andreas Meinitzer, Christiane Drechsler, Eberhard Ritz, Vera Krane, Christoph Wanner, Bernhard O Böhm, Winfried März |
Journal | Stroke
(Stroke)
Vol. 42
Issue 4
Pg. 1132-4
(Apr 2011)
ISSN: 1524-4628 [Electronic] United States |
PMID | 21311067
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Biomarkers
(analysis, blood)
- Comorbidity
- Coronary Angiography
- Coronary Artery Disease
(blood, diagnostic imaging, mortality)
- Endothelial Cells
(metabolism, pathology)
- Female
- Follow-Up Studies
- Homoarginine
(blood, deficiency)
- Humans
- Male
- Middle Aged
- Mortality
(trends)
- Risk Factors
- Stroke
(blood, diagnostic imaging, mortality)
- Time Factors
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