Prevalence of aspirin resistance in stroke patients in Phramongkutklao Hospital.

Abstract

OBJECTIVE:

To study the prevalence of aspirin resistance in cerebrovascular disease patients in Phramongutklao hospital.

MATERIAL AND METHOD:

The acute ischemic and stable stroke patients who received aspirin at least 60 mg, at least 7 days and the last dose of aspirin at least 24 hours before blood test for platelet aggregation. ADP and Collagen were used as platelet aggregator.

RESULTS:

During July 2007- December 2008, 141 cases of ischemic stroke were enrolled. "Aspirin resistant" was defined as mean aggregation more than 60% both ADP and Collagen. "Aspirin semi-responder" was mean aggregation less than 60% for ADP or Collagen.

CONCLUSION:

Prevalence of aspirin resistance in Phramonkutklao hospital is 56 % (79/141), and there are relationship between aspirin resistance and timing in the first episode of stroke.

• Authors: Samart Nidhinandana, Siriprang Changchit
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 93 Suppl 6 Pg. S51-4 (Nov 2010) ISSN: 0125-2208 [Print] Thailand
• PMID: 21280515 (Publication Type: Journal Article)

Chemical References

• Platelet Aggregation Inhibitors
• Aspirin

Topics

• Adolescent
• Adult
• Aspirin (pharmacology, therapeutic use)
• Drug Resistance
• Female
• Hospitals, Teaching
• Humans
• Male
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)
• Platelet Function Tests
• Prevalence
• Stroke (drug therapy)
• Thailand (epidemiology)
• Treatment Outcome
• Young Adult