Abstract | PURPOSE: METHODS: RESULTS: The productions of serum tumor necrosis factor-α (TNF-α), nitric oxide (NO), and high mobility group box 1 ( HMGB 1) were increased in mice during sepsis, which could be reversed by honokiol. Honokiol could also effectively reduce the increased blood lipid peroxidation and nitrotyrosine in septic mice. Honokiol significantly reversed the inductions of inducible NO synthase and nuclear factor-κB (NF-κB) activation in the lungs of mice during sepsis. Honokiol also effectively rescued the lung edema, lung pathological changes, and lethality in septic mice. CONCLUSIONS:
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Authors | Te I Weng, Hsiao Yi Wu, Chia Wei Kuo, Shing Hwa Liu |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 37
Issue 3
Pg. 533-41
(Mar 2011)
ISSN: 1432-1238 [Electronic] United States |
PMID | 21279327
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Biphenyl Compounds
- Lignans
- Lipopolysaccharides
- lipopolysaccharide, E. coli O26-B6
- honokiol
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Topics |
- Acute Lung Injury
(drug therapy, etiology, immunology, mortality, physiopathology)
- Animals
- Anti-Infective Agents
(administration & dosage, pharmacology, therapeutic use)
- Biphenyl Compounds
(administration & dosage, pharmacology, therapeutic use)
- Endotoxemia
(etiology)
- Inflammation
(prevention & control)
- Lignans
(administration & dosage, pharmacology, therapeutic use)
- Lipopolysaccharides
(administration & dosage, toxicity)
- Male
- Mice
- Mice, Inbred ICR
- Oxidative Stress
(drug effects)
- Sepsis
(complications)
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