The effect of early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome.

Abstract

BACKGROUND:

To evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or nonsustained ventricular tachycardia (NSVT) after acute coronary syndrome (ACS) (ST-elevation myocardial infarction [STEMI], non-STEMI, and unstable angina pectoris).

HYPOTHESIS:

Provided that early and intensive lipid-lowering treatment can reduce ventricular premature beat or non-sustained ventricular tachycardia after ACS.

METHODS:

A total of 586 patients with ACS were randomly divided into 2 groups: group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and group B (early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded with Holter monitoring after hospitalization (24 hours and 72 hours).

RESULTS:

Seventy-seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more often had myocardial infarction, diabetes mellitus, atrial fibrillation, and an ejection fraction < 40% in their history. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 hours, P < 0.01; 72 hours, P < 0.001). A significant reduction in NSVT was seen in the early and aggressive (24 hours, P < 0.01; 72 hours, P < 0.001) group. No side effects were observed in either group.

CONCLUSIONS:

Early and intensive lipid-lowering treatment can obviously decrease ventricular premature beats and NSVT.

• Authors: Xian-Zhi He, Sheng-Hua Zhou, Xin-Hong Wan, Hai-Yu Wang, Qing-Hua Zhong, Jian-Fang Xue
• Journal: Clinical cardiology (Clin Cardiol) Vol. 34 Issue 1 Pg. 59-63 (Jan 2011) ISSN: 1932-8737 [Electronic] United States
• PMID: 21259280 (Publication Type: Journal Article, Randomized Controlled Trial, Retracted Publication)
• Copyright: Copyright © 2010 Wiley Periodicals, Inc.

Chemical References

• Anti-Arrhythmia Agents
• Heptanoic Acids
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Pyrroles
• Atorvastatin

Topics

• Acute Coronary Syndrome (complications, drug therapy)
• Aged
• Anti-Arrhythmia Agents (administration & dosage)
• Atorvastatin
• Chi-Square Distribution
• China
• Double-Blind Method
• Drug Administration Schedule
• Electrocardiography, Ambulatory
• Female
• Heptanoic Acids (administration & dosage)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage)
• Male
• Middle Aged
• Pyrroles (administration & dosage)
• Risk Assessment
• Risk Factors
• Tachycardia, Ventricular (diagnosis, etiology, prevention & control)
• Time Factors
• Treatment Outcome
• Ventricular Premature Complexes (diagnosis, etiology, prevention & control)