[Repetition of Helicobacter cinaedi infections during chemotherapy for malignant lymphoma].

Abstract

A 70-year-old male, who had undergone resection of gastric malignant lymphoma in 1992, presented with cervical lymph node swelling in January 2008. Pathological examination of the lymph node biopsy demonstrated recurrence of malignant lymphoma, and he was treated with the R-CHOP regimen. Although he did not develop fever during the first through third course of R-CHOP, from the fourth course, he repeatedly demonstrated fever over 38°C for about one week after each course of chemotherapy, despite the absence of neutropenia. Helicobacter cinaedi infection was confirmed by blood culture each time. Although it is difficult to diagnose Helicobacter cinaedi infection by the standard culture method, increased numbers of recent reports especially in immunocompromised patients have emphasized the importance of diagnosing Helicobacter cinaedi infection.

• Authors: Masayoshi Ono, Shunsuke Ohnishi, Reizo Onishi, Shojiro Takahashi, Yoshimitsu Kobayashi, Mio Suzuki, Kimitoshi Kubo, Masayoshi Dazai, Junji Yamamoto, Hisashi Oda, Kenji Tada, Tatsuro Takahashi, Takuto Miyagishima
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 51 Issue 12 Pg. 1781-5 (Dec 2010) ISSN: 0485-1439 [Print] Japan
• PMID: 21258189 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisolone
• Ofloxacin

Topics

• Aged
• Anti-Bacterial Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cephalosporins (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Helicobacter (isolation & purification)
• Helicobacter Infections (diagnosis, drug therapy, etiology, microbiology)
• Humans
• Immunocompromised Host
• Lymphoma, Large B-Cell, Diffuse (complications, drug therapy)
• Male
• Neoplasm Recurrence, Local
• Ofloxacin (administration & dosage)
• Prednisolone (administration & dosage)
• Remission Induction
• Stomach Neoplasms (complications, drug therapy)
• Vincristine (administration & dosage)
• Cefozopran