[A long-term disease-free survival case of advanced rectal cancer with massive metastasis to the lateral pelvic and para-aortic lymph nodes].

Abstract

A 42-year-old man with advanced rectal cancer underwent a low anterior resection with TME and pelvic lateral lymph-node and paraaortic lymph-node dissections. Pathological examination revealed as Type 2, 84 × 70 mm, tub 2 > por, A-SE, int, INF b, ly3, v1, pN3 (35/68), M1 (No. 216: 24/37), Stage IV (Cur B) by Japanese Classification of Colorectal Carcinoma. Three kinds of chemotherapy, 3 courses of irinotecan and bolus fluorouracil plus Leucovorin (IFL), 4 courses of irinotecan and S-1 (IRIS), and one-year of S-1 were administered sequentially. After 5 years from the operation, the patient survived and showed no sign of recurrence. Aggressive lymph-node dissection for rectal cancer patients with massive lymph-node metastasis followed by intensive chemotherapy may result in long-term survival.

• Authors: Tatsushi Shingai, Masayuki Ohue, Shingo Noura, Shingo Kano, Kunihito Gotoh, Masaaki Motoori, Hidenori Takahashi, Kentaro Kishi, Terumasa Yamada, Isao Miyashiro, Hiroaki Ohigashi, Masahiko Yano, Osamu Ishikawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 12 Pg. 2608-10 (Nov 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 21224654 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Drug Combinations
• Vitamin B Complex
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Adult
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Aorta, Abdominal
• Camptothecin (administration & dosage, analogs & derivatives)
• Combined Modality Therapy
• Disease-Free Survival
• Drug Administration Schedule
• Drug Combinations
• Fluorouracil (administration & dosage)
• Humans
• Irinotecan
• Leucovorin (administration & dosage)
• Lymph Node Excision
• Lymphatic Metastasis (pathology)
• Male
• Oxonic Acid (administration & dosage)
• Pelvis
• Rectal Neoplasms (mortality, pathology, therapy)
• Tegafur (administration & dosage)
• Vitamin B Complex (administration & dosage)