Abstract | BACKGROUND: Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis, evidences suggesting endogenous opioid peptide link in spinal antinociception of COX inhibitor have been reported. We investigated the roles of opioid receptor subtypes in the spinal antinociception of selective COX-2 inhibitor. METHODS: RESULTS: Intrathecal DUP-697 reduced the flinching response evoked by formalin injection during phase 1 and 2. Naltrindole and GNTI attenuated the antinociceptive effect of intrathecal DUP-697 during both phases of the formalin test. CTOP reversed the antinociception of DUP-697 during phase 2, but not during phase 1. CONCLUSIONS:
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Authors | Cheol Hun Choi, Woong Mo Kim, Hyung Gon Lee, Cheol Won Jeong, Chang Mo Kim, Seong Heon Lee, Myung Ha Yoon |
Journal | The Korean journal of pain
(Korean J Pain)
Vol. 23
Issue 4
Pg. 236-41
(Dec 2010)
ISSN: 2093-0569 [Electronic] Korea (South) |
PMID | 21217886
(Publication Type: Journal Article)
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