Phencyclidine (PCP, I) and most its derivatives have demonstrated some pharmacological effects. Accordingly, in this study, the new methoxy (III) and hydroxy-methyl (IV)
morpholine PCP derivatives were synthesized. The acute and
chronic pain activities of these drugs (III, IV) were investigated by tail immersion and
formalin tests on rats and the results were compared with those in PCP, PCM (PCP-
morpholine, II), and methyl-PCM (V). Findings indicated that III (6 mg/kg, i.p.) generates more
analgesic effects in tail immersion test in comparison with I and II in 20, 40, 45 and 55 min post-injection. These effects were observed in 10, 20, 40, 45 and 50 min after the application of IV (at the same dosage). This
analgesic effect was markedly seen in 20, 40, 45 and 50 min after compound IV's application in comparison with the drugs (I-V). In
formalin test analysis, the acute chemical
pain (Phase I) could not be affected by any drugs (I-V) while chronic
formalin pain would be diminished by these new
synthesized drugs (III and IV), especially in late Phase II, compared to I and II at the dosage of 6 mg/kg. It is, therefore, concluded that these new synthesized PCP derivates including methoxy-PCM (III) and hydroxy-methyl-PCM (IV) could substantially and respectively diminish acute thermal and chronic chemical pains.