Management of patients with incident fractures during osteoporosis treatment.

Abstract

Official recommendations are available for detecting osteoporosis and initiating osteoporosis medications in postmenopausal women. However, there are no recommendations about the management of patients with incident fractures despite osteoporosis therapy. Second-line osteoporosis treatments have been evaluated only based on laboratory and absorptiometry criteria. Nevertheless, we will try to answer the following questions: (1) What criteria should be used to determine whether a fracture during osteoporosis treatment indicates treatment failure (low-energy fracture, fracture not due to an intercurrent health condition, fracture of the type targeted by the osteoporosis treatment, sufficient treatment duration at occurrence of the fracture, and good adherence to the treatment and to vitamin D supplementation)? (2) In patients with treatment failure or an inadequate clinical response, defined as a fracture despite adherence to osteoporosis therapy for at least 1 year, what are the best treatment strategies?

• Authors: Nadia Mehsen, Julien Paccou, Cyrille B Confavreux, Claire David, Ariane Leboime, Michel Laroche
• Journal: Joint bone spine (Joint Bone Spine) Vol. 77 Suppl 2 Pg. S133-8 (Dec 2010) ISSN: 1778-7254 [Electronic] France
• PMID: 21211751 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Bone Density Conservation Agents
• Calcium Compounds

Topics

• Bone Density Conservation Agents (therapeutic use)
• Calcium Compounds (administration & dosage)
• Dietary Supplements
• Drug Substitution
• Female
• Fracture Healing (drug effects)
• Fractures, Stress (complications, pathology)
• Humans
• Osteoporosis, Postmenopausal (complications, drug therapy, pathology)
• Osteoporotic Fractures (etiology, pathology, therapy)
• Patient Compliance
• Treatment Failure
• Vitamin D Deficiency (complications)
• Withholding Treatment