Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis.

Abstract

OBJECTIVE:

We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D) concentrations) with prostate cancer.

METHODS:

We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response random-effects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I(2) statistic quantified between-study variation due to heterogeneity.

RESULTS:

Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I (2) = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I (2) = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I (2) = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I (2) = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I (2) = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)(2)D was 1.00 (7 studies; 0.87, 1.14; I (2) = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I (2) = 0%) for aggressive prostate cancer.

CONCLUSION:

Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.

• Authors: Rebecca Gilbert, Richard M Martin, Rebecca Beynon, Ross Harris, Jelena Savovic, Luisa Zuccolo, Geertruida E Bekkering, William D Fraser, Jonathan A C Sterne, Chris Metcalfe
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 22 Issue 3 Pg. 319-40 (Mar 2011) ISSN: 1573-7225 [Electronic] Netherlands
• PMID: 21203822 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)

Chemical References

• Vitamins
• Vitamin D

Topics

• Case-Control Studies
• Diet
• Humans
• Male
• Odds Ratio
• Prospective Studies
• Prostatic Neoplasms (etiology)
• Risk
• Vitamin D (pharmacology)
• Vitamins (pharmacology)