Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies.

Abstract

The bacilli Calmette-Guérin (BCG) vaccine is administered to all newborns in countries where tuberculosis is endemic. Immunocompromised hosts, namely patients with human immunodeficiency virus infection or primary immunodeficiencies, are especially prone to serious complications from this vaccine. We report three cases of BCG disease in children with primary immunodeficiencies: one with a partial recessive interferon-γ receptor 1 deficiency, who developed BCG dissemination; and two relatives with ZAP70 deficiency, a severe combined immunodeficiency, both of whom presented with regional and distant BCG disease. All had severe axillary lymphadenitis. These clinical cases underline the importance of considering the diagnosis of immunodeficiency in a child with severe axillary lymphadenitis after BCG vaccination and of disseminated BCG disease in an immunodeficient child in the appropriate clinical setting. Moreover, BCG vaccination should be delayed in every newborn with a family history of primary immunodeficiency until the condition has been ruled out.

• Authors: Alexandra Santos, Andrea Dias, Ana Cordeiro, Carolina Cordinhã, Sónia Lemos, Graça Rocha, Emília Faria
• Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (J Microbiol Immunol Infect) Vol. 43 Issue 6 Pg. 530-7 (Dec 2010) ISSN: 1995-9133 [Electronic] England
• PMID: 21195982 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved.

Chemical References

• BCG Vaccine
• Receptors, Interferon
• ZAP-70 Protein-Tyrosine Kinase

Topics

• BCG Vaccine (administration & dosage, adverse effects)
• Female
• Humans
• Immunologic Deficiency Syndromes (complications)
• Infant
• Lymphadenitis (microbiology)
• Male
• Mycobacterium bovis (immunology)
• Receptors, Interferon (deficiency)
• Severe Combined Immunodeficiency (complications)
• Tuberculosis (diagnosis, microbiology, prevention & control)
• Vaccination (adverse effects)
• ZAP-70 Protein-Tyrosine Kinase (deficiency)
• Interferon gamma Receptor