NF-κB, inflammation, and metabolic disease.

Abstract

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

• Authors: Rebecca G Baker, Matthew S Hayden, Sankar Ghosh
• Journal: Cell metabolism (Cell Metab) Vol. 13 Issue 1 Pg. 11-22 (Jan 05 2011) ISSN: 1932-7420 [Electronic] United States
• PMID: 21195345 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Inflammation Mediators
• NF-kappa B
• Protein Serine-Threonine Kinases

Topics

• Animals
• Humans
• Inflammation (genetics, physiopathology)
• Inflammation Mediators (immunology, metabolism)
• Macrophages (immunology, pathology)
• Metabolic Diseases (genetics, immunology, metabolism, physiopathology)
• NF-kappa B (antagonists & inhibitors, immunology, physiology)
• Protein Serine-Threonine Kinases (antagonists & inhibitors, physiology)
• NF-kappaB-Inducing Kinase