Etiological role of cigarette smoking in rheumatoid arthritis: Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice.

Abstract

Cigarette smoking is a major environmental risk factor for rheumatoid arthritis (RA). However, the experimental bases supporting the etiological role of cigarette smoking in RA have not been fully provided. We have reported that cigarette smoke condensate (CSC), by means of subcutaneous injection into DBA/1J mice with collagen and complete Freund's adjuvant or intraperitoneal injection one day before immunization, augmented the development of arthritis in the mouse model of collagen type II-induced arthritis (CIA). However, these experimental procedures may not be appropriate for cigarette smoking. In this study, we nasally exposed mice to mainstream CSC and found that CSC augmented the induction and development of arthritis and antibody level against collagen. Histological examination confirmed the augmenting effect of CSC. These findings provide experimental bases supporting the etiological role of cigarette smoking in RA.

• Authors: Shosuke Okamoto, Miki Adachi, Satomi Chujo, Kyohei Yamada, Kunihiko Akita, Saotomo Itoh, Takemasa Takii, Kazuichi Hayakawa, Kikuo Onozaki
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 404 Issue 4 Pg. 1088-92 (Jan 28 2011) ISSN: 1090-2104 [Electronic] United States
• PMID: 21195061 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Topics

• Animals
• Arthritis, Experimental (etiology, pathology)
• Male
• Mice
• Mice, Inbred DBA
• Smoking (adverse effects)
• Nicotiana (adverse effects)