Abstract | BACKGROUND: METHODS: Immunohistochemistry and Western blot analysis were applied to detect ADAM 10 expression levels in metastatic cancer tissues, corresponding primary adenoid cystic carcinoma tissues, adenoid cystic carcinoma cell lines with high metastatic potential, and adenoid cystic carcinoma cell lines with low metastatic potential. RNA interference was used to knockdown ADAM 10 expression in adenoid cystic carcinoma cell lines with high metastatic potential. Furthermore, the invasive and metastatic potentials as well as the proliferation capability of the treated cells were observed in vitro and in vivo. RESULTS: CONCLUSIONS:
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Authors | Qin Xu, Xiuming Liu, Wantao Chen, Zhiyuan Zhang |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 8
Pg. 136
(Dec 20 2010)
ISSN: 1479-5876 [Electronic] England |
PMID | 21171968
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Membrane Proteins
- RNA, Messenger
- Amyloid Precursor Protein Secretases
- ADAM Proteins
- ADAM10 Protein
- ADAM10 protein, human
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Topics |
- ADAM Proteins
(genetics, metabolism)
- ADAM10 Protein
- Amyloid Precursor Protein Secretases
(genetics, metabolism)
- Animals
- Carcinoma, Adenoid Cystic
(enzymology, genetics, pathology)
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans
- Immunohistochemistry
- Membrane Proteins
(genetics, metabolism)
- Mice
- Neoplasm Metastasis
- RNA Interference
- RNA, Messenger
(genetics, metabolism)
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