Abstract | PURPOSE OF REVIEW: To discuss inherited iron disorders, their pathophysiology and clinical implications in the light of the recent advances in our knowledge of iron metabolism and its regulation. RECENT FINDINGS: SUMMARY: Advances in basic research have improved the classification and diagnosis of genetic anemias and iron overload and are paving the way towards the development of drugs that target the molecular lesions.
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Authors | Clara Camaschella, Erika Poggiali |
Journal | Current opinion in pediatrics
(Curr Opin Pediatr)
Vol. 23
Issue 1
Pg. 14-20
(Feb 2011)
ISSN: 1531-698X [Electronic] United States |
PMID | 21150441
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antimicrobial Cationic Peptides
- HAMP protein, human
- Hepcidins
- Membrane Proteins
- Serine Endopeptidases
- TMPRSS6 protein, human
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Topics |
- Antimicrobial Cationic Peptides
(metabolism)
- Child
- Genetic Predisposition to Disease
(genetics)
- Hepcidins
- Humans
- Iron Metabolism Disorders
(diagnosis, genetics, metabolism, physiopathology)
- Membrane Proteins
(deficiency)
- Serine Endopeptidases
(deficiency)
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