The IP(3) receptor-mitochondria connection in apoptosis and autophagy.

Abstract

The amount of Ca(2+) taken up in the mitochondrial matrix is a crucial determinant of cell fate; it plays a decisive role in the choice of the cell between life and death. The Ca(2+) ions mainly originate from the inositol 1,4,5-trisphosphate (IP(3))-sensitive Ca(2+) stores of the endoplasmic reticulum (ER). The uptake of these Ca(2+) ions in the mitochondria depends on the functional properties and the subcellular localization of the IP(3) receptor (IP(3)R) in discrete domains near the mitochondria. To allow for an efficient transfer of the Ca(2+) ions from the ER to the mitochondria, structural interactions between IP(3)Rs and mitochondria are needed. This review will focus on the key proteins involved in these interactions, how they are regulated, and what are their physiological roles in apoptosis, necrosis and autophagy. This article is part of a Special Issue entitled: 11th European Symposium on Calcium.

• Authors: Jean-Paul Decuypere, Giovanni Monaco, Geert Bultynck, Ludwig Missiaen, Humbert De Smedt, Jan B Parys
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1813 Issue 5 Pg. 1003-13 (May 2011) ISSN: 0006-3002 [Print] Netherlands
• PMID: 21146562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: 2010 Elsevier B.V. All rights reserved.

Chemical References

• Inositol 1,4,5-Trisphosphate Receptors
• Mitochondrial Proteins

Topics

• Animals
• Apoptosis
• Autophagy
• Calcium Signaling
• Humans
• Inositol 1,4,5-Trisphosphate Receptors (metabolism)
• Mitochondria (metabolism)
• Mitochondrial Proteins (metabolism)