Abstract | BACKGROUND: AIM: METHODS: We conducted a PubMed search using the following key words: autoimmune pancreatitis, IgG4-associated systemic disease, IgG4-associated cholangitis, diagnosis, natural history, treatment. RESULTS: Although there are reports of spontaneous resolution of autoimmune pancreatitis, steroids have been shown to be effective in inducing remission, reducing the frequency of relapse and that of long-term unfavourable events compared to historical controls. There are no randomised data on autoimmune pancreatitis treatment. Oral steroids are used for induction of remission. Reported response results are excellent with variable proportions of patients achieving remission in different studies. After a period of 2-4 weeks, steroids are tapered and usually withdrawn within several months, although long-term maintenance therapy for all autoimmune pancreatitis patients has also been proposed. Disease relapse occurs in more than 40% of patients and can be effectively treated with additional immunosuppression, including azathioprine. CONCLUSIONS:
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Authors | E Kalaitzakis, G J M Webster |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 33
Issue 3
Pg. 291-303
(Feb 2011)
ISSN: 1365-2036 [Electronic] England |
PMID | 21138452
(Publication Type: Journal Article, Review)
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Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- Immunoglobulin G
- Steroids
|
Topics |
- Autoimmune Diseases
(drug therapy, immunology, pathology)
- Humans
- Immunoglobulin G
(immunology)
- Pancreatitis
(drug therapy, immunology, pathology)
- Remission Induction
- Steroids
(therapeutic use)
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