4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.

Abstract

There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labeled amino acids are interesting probes for tumor specific PET imaging. As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[(18)F]fluoro l-glutamic acid (BAY 85-8050) as a new specific PET tracer was established. Cell-uptake studies revealed specific tumor cell accumulation.

• Authors: Raisa N Krasikova, Olga F Kuznetsova, Olga S Fedorova, Yuri N Belokon, Viktor I Maleev, Linjing Mu, Simon Ametamey, P August Schubiger, Matthias Friebe, Mathias Berndt, Norman Koglin, Andre Mueller, Keith Graham, Lutz Lehmann, Ludger M Dinkelborg
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 54 Issue 1 Pg. 406-10 (Jan 13 2011) ISSN: 1520-4804 [Electronic] United States
• PMID: 21128591 (Publication Type: Journal Article)

Chemical References

• Fluorine Radioisotopes
• Glutamates
• Radiopharmaceuticals
• 4-fluoroglutamic acid

Topics

• Cell Line, Tumor
• Fluorine Radioisotopes
• Glutamates (chemical synthesis, chemistry, metabolism)
• Humans
• Isotope Labeling
• Positron-Emission Tomography
• Radiopharmaceuticals (chemical synthesis, chemistry, metabolism)
• Stereoisomerism