Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects.

Abstract

PURPOSE:

Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.

METHODS:

We sought correlations between plasma apoM and PCSK9, measured using recently developed ELISAs, in 79 non-diabetic subjects.

RESULTS:

ApoM and PCSK9 levels were both correlated positively with total cholesterol, non-HDL cholesterol, LDL cholesterol and apoB (P < 0.05 to P < 0.001). ApoM correlated positively with PCSK9 in lean individuals (n = 37, r = 0.337, P = 0.041), but not in overweight subjects (n = 32, r = 0.125, P = 0.50) and in obese subjects (n = 10, r = -0.055, P = 0.88).

CONCLUSIONS:

The PCSK9 pathway may contribute to plasma apoM regulation in humans. The influence of PCSK9 on circulating apoM appears to be modified by adiposity.

• Authors: Paul J W H Kappelle, Gilles Lambert, Björn Dahlbäck, Lars Bo Nielsen, Robin P F Dullaart
• Journal: Atherosclerosis (Atherosclerosis) Vol. 214 Issue 2 Pg. 492-4 (Feb 2011) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 21122852 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010. Published by Elsevier Ireland Ltd.

Chemical References

• APOM protein, human
• Apolipoproteins
• Apolipoproteins B
• Apolipoproteins M
• Biomarkers
• Cholesterol, LDL
• Lipocalins
• Cholesterol
• PCSK9 protein, human
• Proprotein Convertase 9
• Proprotein Convertases
• Serine Endopeptidases

Topics

• Adiposity
• Aged
• Apolipoproteins (blood)
• Apolipoproteins B (blood)
• Apolipoproteins M
• Biomarkers (blood)
• Body Mass Index
• Cholesterol (blood)
• Cholesterol, LDL (blood)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Lipocalins
• Middle Aged
• Netherlands
• Obesity (blood, physiopathology)
• Overweight (blood, physiopathology)
• Proprotein Convertase 9
• Proprotein Convertases
• Regression Analysis
• Serine Endopeptidases (blood)