[The enhanced clinical efficacy by treated years and the sustained efficacy after treatment of sublingual immunotherapy for Japanese cedar pollinosis].

Abstract

BACKGROUND:

Although sublingual immunotherapy (SLIT) is hopeful therapy for seasonal allergic rhinitis by Japanese cedar pollen, there are many issues to study. We studied the adding effects on clinical efficacy by the treated years and sustained efficacy 1 year after a 3-year period of SLIT.

METHODS:

Clinical efficacy of SLIT in patients with Japanese cedar pollinosis treated for different years of 1 year (n=7), 2 years (n=18) or 4 years (n=5) were compared in 2009. Patients, who finished SLIT after a 3-year period and did not received SLIT at the fourth year (n=12), was also compared with those who received SLIT at the fourth year (n=5).

RESULTS:

By adding treated year, clinical efficacy of sneezing, rhinorrhea and congestion became better, and symptom-medication score (SMS) was significantly better in the fourth year of SLIT. Patients with the fourth year of SLIT showed better SMS compared with those who finished at the third year.

CONCLUSION:

Consecutive treatment of SLIT showed better efficacy. Although it was recommended to continue SLIT therapy at least four years, it needed further study because of small number of patients.

• Authors: Atsushi Yuta, Hitomi Ogihara, Yukiko Miyamoto, Kazuhiko Takeuchi, Kimihiro Okubo
• Journal: Arerugi = [Allergy] (Arerugi) Vol. 59 Issue 11 Pg. 1552-61 (Nov 2010) ISSN: 0021-4884 [Print] Japan
• PMID: 21119301 (Publication Type: English Abstract, Journal Article)

Chemical References

• Allergens

Topics

• Administration, Sublingual
• Adult
• Allergens (administration & dosage)
• Cryptomeria
• Desensitization, Immunologic (methods)
• Female
• Humans
• Male
• Middle Aged
• Rhinitis, Allergic, Seasonal (therapy)
• Time Factors