Angioneurotic edema with risperidone: a case report and review of literature.

Abstract

Angioedema is characterised by oedema of the deep dermal and subcutaneous tissues and is reported as a rare adverse cutaneous reaction with risperidone, clozapine, ziprasidone, droperidol and chlorpromazine. Here we report a case of angioedema with risperidone. A 15-year-old boy diagnosed with schizophrenia was started on risperidone 1 mg/day, which was increased to 2 mg/day after 2 weeks. Within a week of increasing risperidone, he developed swelling over the face and feet. On examination he was found to have periorbital oedema and swollen lips. Following this, risperidone was stopped. Over the period of 1 week his oedema subsided, following which he was started on Haloperidol 5 mg/day, with which his psychosis improved significantly.

• Authors: Ramachandran Naik Soumya, Sandeep Grover, Alakananda Dutt, Navendu Gaur
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2010 Nov-Dec Vol. 32 Issue 6 Pg. 646.e1-3 ISSN: 1873-7714 [Electronic] United States
• PMID: 21112458 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Antipsychotic Agents
• Haloperidol
• Risperidone

Topics

• Adolescent
• Angioedema (chemically induced, diagnosis)
• Antipsychotic Agents (adverse effects, therapeutic use)
• Diagnosis, Differential
• Dose-Response Relationship, Drug
• Drug Substitution
• Haloperidol (therapeutic use)
• Humans
• Male
• Risperidone (adverse effects, therapeutic use)
• Schizophrenia (diagnosis, drug therapy)