Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.

Abstract

Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino)piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.

• Authors: Ken'ichi Kura, Takaaki Kubota, Jane Fromont, Jun'ichi Kobayashi
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 1 Pg. 267-70 (Jan 01 2011) ISSN: 1464-3405 [Electronic] England
• PMID: 21111621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Alkaloids
• Pyridines
• pyrinodemin E
• pyrinodemin F
• pyridine

Topics

• Alkaloids (chemistry, isolation & purification, toxicity)
• Animals
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Magnetic Resonance Spectroscopy
• Mice
• Molecular Conformation
• Porifera (chemistry)
• Pyridines (chemistry, isolation & purification, toxicity)