Abstract | AIM: The Japan EPA Lipid Intervention Study (JELIS) was the first prospective randomized clinical trial to demonstrate prevention of coronary events by pure eicosapentaenoic acid (EPA). The aim of this study was to examine the relationships between various plasma fatty acid concentrations and the risk of coronary events in JELIS participants. METHODS: RESULTS: As a result of EPA intervention, the plasma EPA concentration increased, but the docosahexaenoic acid (DHA) concentration did not. The other fatty acids measured decreased slightly. The higher plasma level of EPA (hazard ratio=0.83, p=0.049, in all participants and hazard ratio=0.71, p=0.018, in the EPA intervention group), but not of DHA, was inversely associated with the risk of major coronary events. The associations between other fatty acids and the risk of major coronary events were not significant. In all JELIS participants, the risk of major coronary events was significantly decreased (20%) in the group with high (150 µg/mL or more) on-treatment plasma EPA concentration compared with that in the low (less than 87 µg/mL) group. CONCLUSION:
|
Authors | Hiroshige Itakura, Mitsuhiro Yokoyama, Masunori Matsuzaki, Yasushi Saito, Hideki Origasa, Yuichi Ishikawa, Shinichi Oikawa, Jun Sasaki, Hitoshi Hishida, Toru Kita, Akira Kitabatake, Noriaki Nakaya, Toshiie Sakata, Kazuyuki Shimada, Kunio Shirato, Yuji Matsuzawa, JELIS Investigators |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 18
Issue 2
Pg. 99-107
( 2011)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 21099130
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Fatty Acids
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
|
Topics |
- Aged
- Coronary Artery Disease
(blood, etiology, prevention & control)
- Docosahexaenoic Acids
(blood)
- Eicosapentaenoic Acid
(blood, pharmacology)
- Fatty Acids
(blood, chemistry)
- Female
- Humans
- Japan
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
|