Diagnosis of antiphospholipid syndrome.

Abstract

Antiphospholipid syndrome is a multisystem autoimmune disease, characterized by recurrent vascular thrombosis and/or pregnancy losses in the presence of persistently positive antiphospholipid antibodies. In clinical practice, testing for anticardiolipin antibodies and lupus anticoagulant is mandatory for the laboratory diagnosis of antiphospholipid syndrome. Identification of patients with antiphospholipid syndrome is important, as prophylactic anticoagulant therapy may prevent thrombosis from recurring, and treatment during pregnancy can improve fetal and maternal outcome.

• Authors: Maria Laura Bertolaccini, Munther A Khamashta
• Journal: Expert review of hematology (Expert Rev Hematol) Vol. 1 Issue 2 Pg. 183-8 (Dec 2008) ISSN: 1747-4094 [Electronic] England
• PMID: 21082923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Anticardiolipin
• Anticoagulants
• Lupus Coagulation Inhibitor

Topics

• Adult
• Antibodies, Anticardiolipin (analysis, immunology)
• Anticoagulants (therapeutic use)
• Antiphospholipid Syndrome (diagnosis, immunology, therapy)
• Female
• Humans
• Lupus Coagulation Inhibitor (analysis, immunology)
• Middle Aged
• Pregnancy
• Prospective Studies