Noninflammatory cerebral vasculopathy associated with recurrent ischemic strokes.

Abstract

Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.

• Authors: James S McKinney, Jonathan M Raser, Miguel A Guzman, William W Schlaepfer, Brett L Cucchiara, Steven R Messé, Lauren H Sansing, Scott E Kasner
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 21 Issue 5 Pg. 417-21 (Jul 2012) ISSN: 1532-8511 [Electronic] United States
• PMID: 21075007 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Biopsy
• Brain (blood supply, pathology)
• Brain Ischemia (diagnosis, etiology)
• Cerebral Angiography
• Humans
• Male
• Recurrence
• Stroke (diagnosis, etiology)