[Study on the gene polymorphismand the levels of α₁-antitrypsin (α1-AT) in patients with lung cancer in Harbin].

Abstract

BACKGROUND:

To study the gene polymorphism and the dynamic changes of the level of α₁-antitrypsin(α₁-AT) in patients with lung cancer of Chinese Han race in Harbin and its clinical significance.

METHODS:

The phenotypes of α₁-AT from 99 patients with lung cancer and 749 normal persons were determined by polyacrylamide gel isoelectricfocusing electrophoresis. The levels of α₁-AT in serum were determined by monophonic immunodiffusion.

RESULTS:

The common subtypes, such as M₁M₁ , M₁M₂ , M₂M₃, etc, were positive and the deficiency subtype was negative in both of the two groups. There was no significant difference in phenotypes and gene frequencies between the two groups ( P > 0. 05) . The level of α₁-AT in patients with lung cancer were remarkably higher than that in normal group ( P < 0. 05) , and significantly increased after anti-inflammatory or/and chemical treatment ( P < 0. 05) .

CONCLUSIONS:

There is no significant difference in gene polymorphism of α₁-AT between the patients with lung cancer and normal persons, but the dynamic changes of α₁-AT are valuable to differentiate inflammation from cancer, estimate the efficacy of chemotherapy, and formulate and adjust the treatment scheme.

• Authors: J Huo, S Yu, H Sun, Y Shi
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 4 Issue 5 Pg. 327-9 (Oct 20 2001) ISSN: 1009-3419 [Print] China
• PMID: 21059308 (Publication Type: English Abstract, Journal Article)